Endocrine Abstracts

Aims: To compare glycaemic control and weight gain in children with type 1 diabetes changing from twice daily premixed insulin to multiple daily injections (MDI) with either insulin glargine or insulin detemir.Methods: A retrospective study of 41 consecutive children and adolescents with type 1 diabetes, changed to MDI between January 2005 and April 2007, with outcome measures of HbA1C change and body mass index SDS (BMI-SDS) change after 12 months of MD...

Introduction: IGF-I and its binding proteins may modulate cardiovascular risk. As part of our Manchester Mothers’ Cardiovascular study, we tested in pre-menopausal women the hypothesis that higher circulating IGF-I concentrations would be associated with lesser arterial stiffness and lower cardiac (LV) mass, while higher IGFBP1, reflecting less pre-hepatic insulin, would be positively related to small vessel function.Methods: About 193 women aged 32...

Case PresentationA 25-year-old lady presented with symptomatic hyperthyroidism. She had a 4–6-week history of unexplained weight loss, pain in her neck and difficulty swallowing. Bloods confirmed mild hyperthyroidism with TSH 0.19 mU/l (reference range 0.27-4.2) with free T4 24.4 pmol/l (reference range 12.0-22.0), and she was commenced on carbimazole. There was no evidence of inflammation with CRP < 1 mg/l. Her mother had a thyroidectom...

Background: In the UK, 1 to 4 per 1000 people have primary hyperparathyroidism (PHPT) and are at risk of hypercalcaemia and its complications. Whilst surgery is the only curative option in the management of PHPT, several patients are managed conservatively or medically. Cinacalcet (a calcimimetic) has a role in PHPT management, in those who have declined or are unable to progress to surgery. It is important that the use of Cinacalcet in these cases adheres to ...

A male in his 40’s diagnosed with type 2 diabetes in 2011 (BMI:20.7kg/m2) was admitted with DKA (Dec 2018) after a period of poor glycaemic control on oral hypoglycaemic agents (Feb 2017: HbA1c-105mmol/mol, Nov 2018: HbA1c-115mmol/mol). There was dramatic improvement in glycaemic control after commencing him on subcutaneous insulin (April 2019: HbA1c-56mmol/mol). GAD65 antibodies were positive (24u/mL; normal<5u/mL) and a diagnosis of latent autoimmune diab...

Background: Gonadotroph adenomas are usually clinically non-functioning and hypersecretion of FSH or LH is unusual, and no distinct hormone-dependent clinical phenotype is present. Positive immunostaining for nuclear transcription factor SF1 is usually sufficient to diagnose gonadotroph adenoma.Case History: A 37-year-old lady with Asian background presented with tiredness, headaches, weight gain, poor sleep, secondary amenorrhea and infertility for 2 ye...

Background: Kisspeptin is an RF amide peptide hormone critical for reproductive function. Kisspeptin is also abundantly expressed in the placenta, where it has an important physiological role in regulating placental invasion. Accordingly, plasma kisspeptin levels rise dramatically during normal pregnancy. Lower plasma levels of kisspeptin are associated with poor pregnancy outcomes such as recurrent miscarriage, intrauterine growth restriction and pre-eclampsia. Urinary measur...

Background: Kisspeptin is an RF amide peptide hormone critical for reproductive function. Kisspeptin is also abundantly expressed in the placenta, where it has an important physiological role in regulating placental invasion. Accordingly, plasma kisspeptin levels rise dramatically during normal pregnancy. Lower plasma levels of kisspeptin are associated with poor pregnancy outcomes such as recurrent miscarriage, intrauterine growth restriction and pre-eclampsia. Urinary measur...

LHX3, a LIM-homeodomain transcription factor, plays a critical role in pituitary and nervous system development. Mutations in the LHX3 gene are associated with combined pituitary hormone deficiency disease (CPHD). Two female siblings with neonatal complications were diagnosed with CPHD resulting from a novel, recessive mutation in LHX3. The index patient presented with classical symptoms of CPHD, featuring deficiencies of GH, LH, FSH, prolactin, TSH and later onset ACTH defici...

Case History: A male in his 40’s diagnosed with type 2 diabetes in 2011 (BMI:20.7 kg/m2) was admitted with DKA (Dec 2018) after a period of poor glycaemic control on oral hypoglycaemic agents (Feb 2017: HbA1c-105 mmol/mol, Nov 2018: HbA1c-115 mmol/mol). There was dramatic improvement in glycaemic control after commencing him on subcutaneous insulin (April 2019: HbA1c-56 mmol/mol). GAD65 antibodies were positive (24 u/ml; normal<5 u/ml) and a diagnosis of latent a...